Postdoctoral Researcher Position in Coordination Chemistry for Health
University of Lorraine, L2CM, Nancy, FranceSend a CV, a brief summary of your research experience and two reference names to Dr. Mathilde BOUCHÉ (mathilde.bouche@univ-lorraine.fr). (deadline March 2nd 2025)
Photothermal therapy (PTT) is a highly promising therapeutic option to overcome resistance in cancer therapy. PTT relies on light-to-heat conversion by a photothermal agent. Iron(II) complexes have shown very promising properties as photothermal agents, reaching temperatures far beyond those required in PTT at low millimolar concentration.[1,2] Iron(II) complexes are also active in photoacoustic imaging (PA), an emerging medical imaging technique.[2,3] Therefore, the aim of this project is to synthesize and study iron(II) complexes for photoacoustic imaging guided photothermal therapy.
Objectives:
▪ Synthesize a library of polydentate ligands
▪ Coordinate to iron(II) center
▪ Explore their structure-optical properties relationship
▪ Rationalize their structure-PTT activity relationship
Education: PhD in Synthetic Organic Chemistry, Coordination Chemistry or related fields
Technical skills:
▪ Design and synthesis of organic ligands and coordination to transition metals
▪ Spectroscopic and structural characterization techniques (NMR, mass spectrometry, UV-visible
absorbance…)
▪ Knowledge in optical imaging and anticancer therapy are a plus
▪ English proficiency (spoken & written)
Organic chemistry, Coordination chemistry, Optical imaging, Photothermal therapy.
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