Light-driven Self-propelled Nanozyme
Almudena Marti ( Ass. Prof., L2CM, Nancy)
Robert Wojcieszak (CR CNRS, L2CM, Nancy)
Alida Manjovelo (M2, student)
The ZyLight project aims to develop self-propelled nanozymes for enhanced antimicrobial therapies and biosensing. By combining MoS2 nanosheets (MoS2NFs) with g-C3N4, the project creates a catalytic cascade system that mimics glucose oxidase (GOx) and catalase (CAT) activities, generating hydrogen peroxide (H2O2) and converting it into oxygen for propulsion. The nanozymes are light-activated, enabling targeted therapy with enhanced ROS production and photothermal effects. These features make the nanozymes ideal for treating infections, improving tissue penetration, and enabling motion-based biosensing to detect pathogens. The project focuses on synthesizing and functionalizing MoS2/g-C3N4 nanozymes, optimizing their catalytic activities, and testing their antimicrobial efficacy on bacterial cultures. Additionally, the project will assess the motion of these nanozymes and their performance under light irradiation, enhancing both therapy and detection capabilities. The project has the potential to revolutionize point-of-care diagnostics and antimicrobial treatments, offering a breakthrough in nanomaterial-based therapies.
