UnRavelling the true Nature of INdocyanine green J-Aggregated for photothermal therapy
L2CM (UMR 7053), Nancy : Y. Bernhard (Ass. Prof.), A. Pasc (Prof.), N. Canilho (Ass. Prof.), A. Aguilera-Garrido (Postdoc).
CRAN (UMR 7039) / ICL : H-P. Lassalle (Ass. Prof.), S. Grandemange (Prof.).
LACDR, The Neederlands / iCONM, Japan : Van Guyse (Ass. Prof.), K. Kataoka (Prof.).
Contrast-enhanced photothermal therapy (CE-PTT) is a rapidly advancing field that offers substantial improvements over existing techniques and holds significant potential for expanding the applications of photomedicine. However, its clinical adoption remains constrained, largely due to the limitations of current photothermal agents. The UR-Ninja project aims to overcome these challenges by developing an innovative photothermal agent based on the FDA-approved indocyanine green (ICG), engineered into J-type aggregates (IJA) encapsulated within polymeric nanoparticles. Furthermore, the project seeks to comprehensively investigate the chemical composition and spectroscopic properties of IJA to clarify its true nature, which remains insufficiently understood.
