CDUL BIOCATZYME

BioCATZyme project will develop an innovative nanocatalytic tumor therapy based on a biomimetic cascade reaction, utilizing a multifunctional nanoplatform composed of mesoporous MnO₂ nanoparticles. These nanoparticles exhibit glucose oxidase (GOx-like) and peroxidase (POD-like) activities, enabling the in-situ generation of hydrogen peroxide (H₂O₂) from glucose. The generated H₂O₂ can be decomposed into oxygen (O₂) bubbles, propelling nanomotors to enhance tumor penetration. Additionally, the system utilizes near-infrared (NIR) light activation for controlled photothermal therapy, further boosting reactive oxygen species (ROS) production. The integration of these catalytic nanozymes offers a synergistic effect, combining self-supplied H₂O₂, photothermal therapy, and autonomous motion, which improves therapeutic efficacy while minimizing side effects. This novel approach will enhance targeted cancer treatment, increase bioimaging sensitivity, and overcome challenges in nanomaterial diffusion within tumors. BioCATZyme presents a promising strategy for advanced, efficient, and precise tumor therapy.