Outils Moléculaires pour Imager des Complexes de Fe(II) et leur métabolisation / Molecular Tools to Image Fe(II) Complexes and their Metabolization)
L2CM :
M. BOUCHÉ (CR) principal investigator
P. C. GROS (DR) partner
S. PARANT (IE) photophysics
F. DUPIRE (IE) mass spectrometry
U. CARILLO (postdoc)
CRAN :
S. GRANDEMANGE (Pr) partner
Partner Institution:
French National Centre for Scientific Research (CNRS)
The biological activity of numerous metal complexes is tightly correlated to their stability or reactivity in living systems. Their susceptibility to bio-transformations must be screened early during drug development to orient drug design. The OMIC-Fe(II) project aims at developing innovative photoactive tools to simultaneously track the localization of a series of Fe(II)-based drug candidates, and image their bio-transformations, to understand the intricate relationship between their in cellulo fate and bioactivity.
