Project: Photothermal therapy (PTT) has garnered increasing interest as a potential alternative to conventional therapeutic methods. This technique utilizes molecules or nanoparticles capable of efficiently converting light into heat. Highly challenging research aspects in the field concern the development of fully organic agents with high biosafety, light absorption in the 700-900 nm biologically transparent window, and that provide efficient PTT effect combined with photoacoustic image-guiding strategy. The CD-Mix project aims to investigate the use of cyanine polymer-conjugates for the fabrication of core-cross-linked micelles though the self-assembly of conjugates followed by dimerization of cyanine dyes within micelles, ultimately facilitating image-guided PTT applications.
Position: The work will consist in multistep organic synthesis of Cy-dyes, polymer synthesis of biocompatible polymers through controlled methodologies, self-assembly and micelles core-crosslinked studies, nanoscale and photophysical characterizations, as well as assessment of properties relevant to PTT/PAI applications.
Profile: You should hold a Master degree in organic chemistry or related field, with practical experience in the lab. Interest/experience in polymer chemistry, dyes chemistry or nanoparticle synthesis would be appreciated. Creativity, autonomy, reliability, and organization skills are highly required, together with a strong interest in a multidisciplinary approach. The project offers an exceptional opportunity for a highly motivated student to develop a broad range of competencies within research areas that hold significant academic and industrial relevance.
Application form: Applications should be sent to Dr. Yann Bernhard (yann.bernhard@univ-lorraine.fr). It should include a detailed CV, a cover letter highlighting how you meet the criteria, and your M1/M2 (or equivalent) grades reports.
Campus Aiguillettes, BP 70239
54506 Vandoeuvre-lès-Nancy, France
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Retour à la listePost-Doc : Synthesis of New Photosensitizers for CO2 Photoreduction and Carbonylation Reactions
The project focuses on the development of new photosensitizers and catalysts, based on purely organic materials or more abundant metals, for the photoreduction of CO2 to CO. This research, conducted in collaboration with other groups, aims to investigate the catalytic cycle of these new photosensitizers and catalysts, providing insights into the structure-function relationships of these molecular architectures. The ultimate goal is to design more efficient photocatalysts through a rational approach. Key techniques involved in the project include electrochemistry and electronic and vibrational spectroscopy to identify key intermediate species formed during the catalytic cycle. The performance of new catalysts will be evaluated under photocatalytic conditions, focusing on turnover frequency (TOF), turnover number (TON), and selectivity. The CO produced through photoreduction can be utilized in various carbonylation reactions facilitated by catalysis or photocatalysis.
POSTDOCTORAL POSITION IN PHOTOCHEMISTRY/PHOTOPHYSICS : PHOTOPHYSICAL MECHANISM OF MOLECULAR MOTORS STUDIED BY TRANSITORY ABSORPTION SPECTROSCOPY
We offer an 18-months postdoctoral position to work on the photophysical mechanism of molecular motors (or more generally photoswitches). You will be responsible and/or participate to the following tasks: • Study of the ground state structure and dynamics at molecular and assembled levels • Characterization of excited-state dynamics at molecular and assembled level • Participation in the supervision of PhDs, engineers, and trainees - restoring the results, communication at international conferences, participation in writing of manuscripts.
Keywords: ultrafast spectroscopy • self-assembling • photoswitches • molecular machines