Séminaire de Morgan Donnard

Abstract : Captodative enamides are particularly functionalized building blocks, opening up a wide range of applications in synthetic chemistry, particularly in heterocyclic synthesis. However, access to these compounds remains particularly limited, especially in the case of tetrasubstituted C=C double bonds, due to regio- and stereoselectivity problems. In this lecture, we present the selective and efficient synthetic routes to captodative enamides that we have developed. These syntheses are based on ynamide difunctionalizations, and we will then present our first applications of these building blocks to obtain totally original heterocycles, including unprecedented silacyclic fluorophores.