Séminaire de Sébastien Ulrich

Le 17 Novembre 2023, Salle Jean Barriol

Dr Sébastien Ulrich, DR-CNRS, Institut des Biomolécules Max Mousseron (UMR5247), Université de Montpellier,  donnera une conférence intitulée « Towards smart materials & delivery devices using dynamic covalent chemistry »

Abstract

Dynamic covalent chemistry combines the stability of covalent structures with the constitutional dynamics of supramolecular systems. Therefore, dynamic covalent chemistry enables access to complex chemical systems displaying lifelike behaviors such as self-assembly, adaptation, responsiveness, selection, and self-replication. In this talk, I will show our efforts and present our recent achievements in implementing dynamic covalent chemistry for 1) producing smart vectors of nucleic acids,[1-3] and 2) assembling functional materials from molecular building blocks through hierarchical processes.[4]
References:
[1] Structure-Activity Relationships in Nucleic-Acid-Templated Vectors Based on Peptidic Dynamic
Covalent Polymers, D. D. Su, L. M. A. Ali, M. Coste, N. Laroui, Y. Bessin, M. Barboiu, N. Bettache, S.
Ulrich, Chem. Eur. J., 2023, 29, e202202921.
[2] Cell-selective siRNA delivery using glycosylated dynamic covalent polymers self-assembled in situ
by RNA-templating, N. Laroui, M. Coste, D. Su, L. M. A. Ali, Y. Bessin, M. Barboiu, M. Gary-Bobo, N.
Bettache, S. Ulrich, Angew. Chem. Int. Ed., 2021, 60, 5783.
[3] Growing Prospects of Dynamic Covalent Chemistry in Delivery Applications, S. Ulrich, Acc. Chem.
Res., 2019, 52, 510.
[4] Hierarchical Self-Assembly and Multidynamic Responsiveness of Fluorescent Dynamic Covalent
Networks Forming Organogels, E. Suarez-Picado, M. Coste, J. Y. Runser, M. Fossepre, A. Carvalho,
M. Surin, L. Jierry, S. Ulrich, Biomacromolecules, 2022, 23, 431.